A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

During development, many crucial genes help organisms form properly. One of those genes is myogenic determination gene number 1 (MyoD), which can exert a powerful influence as a “genome organizer." It ...

Crystal structures of the Lac repressor, with and without isopropylthiogalactoside (IPTG), and the repressor bound to operator have provided a model for how the binding of the inducer reduces the ...

A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a new study. A ...

Peer pressure often evokes unexpected behavior, and protein partners might do the same. The Methyl-CpG binding protein 2 (MeCP2) has long been considered a transcriptional repressor, given its ...

Researchers have developed two types of programmable repressor elements that can switch off the production of an output protein in synthetic biology circuits by up to 300-fold in response to almost ...

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond ...