Against the backdrop of wide variability in thrombotic risk and clopidogrel response in patients following percutaneous coronary intervention (PCI) as well as growing use of more potent antiplatelet ...

BARCELONA, Spain—Switching from more potent antiplatelets to clopidogrel based on the results of platelet function testing shortly after PCI seems to be a viable option in patients with ACS, results ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

Barcelona, Spain - 27 Aug 2017: PCSK9 is a co-activator of platelet function beyond its role in cholesterol homeostasis, according to research presented at ESC Congress today.1 The findings suggest ...

Study of the bleeding tendency in uremia in 26 subjects, 10 of whom were bleeding, showed platelet counts and plasma coagulation factors to be normal. There was a significant inverse correlation ...

Use of platelet function testing during dual antiplatelet therapy, including a P2Y12 antagonist, in acute coronary syndromes does not improve clinical outcomes. Researchers at King's College London ...

THE term primary or "spontaneous" hemostasis refers to a complex series of biologic events occurring in immediate response to blood-vessel severance or injury. Although damaged or cut blood vessels ...

Managing drug dosage is critical to the overall success of pharmaceutical intervention, not only in the clinic but also in clinical trials. Inadequate dose management of certain drugs can have fatal ...

Platelets are small types of blood cells that prevent excessive bleeding. It’s possible to develop low or high platelet counts related to a number of health conditions. Platelets are one of the main ...

Scientists have discovered a hitherto unknown function of blood platelets in cancer. In mouse models, these platelets have proved to help preserve the vascular barrier which makes blood-vessel walls ...